An Integrative Approach to Breast Cancer
Tara Scott, MD, FACOG, CNMP, ABAARM, ABOIHM, and Salena Rothenberger, CFMP, CHC
ABSTRACT: There seems to be an increase incidence of premenopausal breast cancer in the United States. Traditionally, HRT has been blamed as a causative factor and also genetics with BRAC 1 and 2. However, these premenopausal patients are not on hormone therapy and many are negative for BRAC genes. My hypothesis is that there are other single nucleotide pleomorphisms (SNPs) that put a patient an increased risk of breast cancer, namely MTHFR 677, MTHFR 1298, and COMT.
MTHFR and COMT genes are involved in methylation processes in the body. This process is a large component of Phase 2 detoxification, especially for estrogen. My theory is that patients with SNPs in MTHFR and COMT have an impaired ability to get rid of estrogens and thus have an accumulation or back up of Estrone or the toxic metabolite 4-OH Estrone which can increase the risk of breast cancer. As a result, there is an imbalance in the hormones that cause hyperplasia (estrogens) and regulation of apoptosis (progesterone) in the breast.
Goals and Objectives:
- Review Estrogen detoxification and discuss epigenetic modulation of the enzymes involved
- Discuss genomics and methylation
- Demonstrate which SNPs may possibly be involved with breast cancer risk
- Provide a literature search on articles already published about methylation and breast cancer risk
- Demonstrate a case study where identifying methylation defects and epigenetic modulation was effective at decreasing harmful 4 OH estrone metabolites.
- Detail a plan to make prevention the target rather than early detection through
- Raising awareness of practitioners regarding methylation and breast cancer, and an integrative approach
- Educate patients about hormone risks factors that are tied to increased breast cancer risk- through the Revitalize Academy
We traditionally think the risk for breast cancer are genes like BRCA 1 & BRCA 2 however, family history, hormone therapy, obesity, reproductive history, radiation history, and alcohol have also been linked.
In 2014, breast cancer resulted in
- 40,000 deaths among individuals in the U.S., with an estimated 232,670 new cases.
Contrary to many cancers that begin to surface after 50 years of age, breast cancer begins to rise at 30 years. Earlier onset is thought to be due to the effects of ovarian hormone on breast tissue.
We will explore the role of estrogen metabolism and key genes in methylation with my theory of excess estrogen as a link to breast cancer through reviewing:
- Functions of hormones and estrogen detoxification
- Review of methylation and basic genetic snps
- Discuss how MTHFR and COMT increase the risk of breast and uterine cancer
- Describe how to be more proactive and preventative
Note: Each section has a video to delve deeper into the slides and you are welcome to reach out to Dr. Scott with any questions.
Click on Image to View Entire Presentation
Learn More at Hormone Guru Academy
Salena Rothenberger partnered with Dr. Tara Scott to create her Hormone Guru Academy. If you are ready to learn what you need to do to optimize your hormones, regain your youthful energy, and most importantly take a preventative approach, click the button to learn more about the workshops, courses, and boot-camps Dr. Tara offers. The content she shares in her academy is the same information she has been teaching medical doctors across the globe for more than a decade.
Looking to connect with someone who "gets it"?
The philosophy at The Functional Perspective is... look not for someone to solve your problems, rather,
someone who will face them along side of you
Book a complimentary call if you are ready for a wellness partner
This is the Final Subheading on the Page
Here, we can ask visitors to connect or share on social media.
Nacogdoches, TX 75965
Additional East Texas locations in: Longview, TX and Lufkin, TX
This site offers health, fitness and nutritional information and is designed for educational purposes only. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional. Do not disregard, avoid or delay obtaining medical or health related advice from your health-care professional because of something you may have read on this site. The use of any information provided on this site is solely at your own risk. The contents of this website have not been evaluated by the FDA nor approved by any other government or official body. Nothing offered online or offline is intended to diagnose, cure or prevent any disease or disorder of any kind.Developments in medical research may impact the health, fitness and nutritional advice that appears here. No assurance can be given that the advice contained in this site will always include the most recent findings or developments with respect to the particular material. If you are in the United States and think you are having a medical or health emergency, call your health care professional, or 911, immediately. Certain health or medical material on this site may be sexually explicit. Please do not use this site if you would find these materials offensive.
© 2021 The Functional Perspective, LLC • Functional Health Mama