An Integrative Approach to Breast Cancer

Tara Scott, MD, FACOG, CNMP, ABAARM, ABOIHM, and Salena Rothenberger, CFMP, CHC

ABSTRACT: There seems to be an increase incidence of premenopausal breast cancer in the United States. Traditionally, HRT has been blamed as a causative factor and also genetics with BRAC 1 and 2. However, these premenopausal patients are not on hormone therapy and many are negative for BRAC genes. My hypothesis is that there are other single nucleotide pleomorphisms (SNPs) that put a patient an increased risk of breast cancer, namely MTHFR 677, MTHFR 1298, and COMT.

MTHFR and COMT genes are involved in methylation processes in the body. This process is a large component of Phase 2 detoxification, especially for estrogen. My theory is that patients with SNPs in MTHFR and COMT have an impaired ability to get rid of estrogens and thus have an accumulation or back up of Estrone or the toxic metabolite 4-OH Estrone which can increase the risk of breast cancer. As a result, there is an imbalance in the hormones that cause hyperplasia (estrogens) and regulation of apoptosis (progesterone) in the breast.

Goals and Objectives:

  • Review Estrogen detoxification and discuss epigenetic modulation of the enzymes involved
  • Discuss genomics and methylation
  • Demonstrate which SNPs may possibly be involved with breast cancer risk
  • Provide a literature search on articles already published about methylation and breast cancer risk
  • Demonstrate a case study where identifying methylation defects and epigenetic modulation was effective at decreasing harmful 4 OH estrone metabolites.
  • Detail a plan to make prevention the target rather than early detection through
  • Raising awareness of practitioners regarding methylation and breast cancer, and an integrative approach
  • Educate patients about hormone risks factors that are tied to increased breast cancer risk- through the Revitalize Academy

We traditionally think the risk for breast cancer are genes like BRCA 1 & BRCA 2 however, family history, hormone therapy, obesity, reproductive history, radiation history, and alcohol have also been linked.

In 2014, breast cancer resulted in


  • 40,000 deaths among individuals in the U.S., with an estimated 232,670 new cases.


Contrary to many cancers that begin to surface after 50 years of age, breast cancer begins to rise at 30 years. Earlier onset is thought to be due to the effects of ovarian hormone on breast tissue.

We will explore the role of estrogen metabolism and key genes in methylation with my theory of excess estrogen as a link to breast cancer through reviewing:

  • Functions of hormones and estrogen detoxification
  • Review of methylation and basic genetic snps
  • Discuss how MTHFR and COMT increase the risk of breast and uterine cancer
  • Describe how to be more proactive and preventative

Note: Each section has a video to delve deeper into the slides and you are welcome to reach out to Dr. Scott with any questions.

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Learn More at Hormone Guru Academy

Salena Rothenberger partnered with Dr. Tara Scott to create her Hormone Guru Academy.  If you are ready to learn what you need to do to optimize your hormones, regain your youthful energy, and most importantly take a preventative approach, click the button to learn more about the workshops, courses, and boot-camps Dr. Tara offers.  The content she shares in her academy is the same information she has been teaching medical doctors across the globe for more than a decade.  

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